The influence of genetics in acquired adult heart disease remains incompletely defined.
Genetic manipulation in mice has been widely used in combination with physiologic
modeling to address this deficiency and has provided insights into the pathophysiology of
myocardial signaling. However, conventional techniques of directed gene expression or
ablation confound adult heart phenotypes with genetic perturbation of embryonic or
postnatal cardiac development. Here, studies of Gαq and Nix, powerful signaling factors for …