[HTML][HTML] Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response
A Haoudi, RC Daniels, E Wong, G Kupfer… - Journal of Biological …, 2003 - ASBMB
The virally encoded oncoprotein Tax has been implicated in HTLV-1-mediated cellular
transformation. The exact mechanism by which this protein contributes to the oncogenic
process is not known. However, it has been hypothesized that Tax induces genomic
instability via repression of cellular DNA repair. We examined the effect of de novo Tax
expression upon the cell cycle, because appropriate activation of cell cycle checkpoints is
essential to a robust damage-repair response. Upon induction of tax expression, Jurkat T …
transformation. The exact mechanism by which this protein contributes to the oncogenic
process is not known. However, it has been hypothesized that Tax induces genomic
instability via repression of cellular DNA repair. We examined the effect of de novo Tax
expression upon the cell cycle, because appropriate activation of cell cycle checkpoints is
essential to a robust damage-repair response. Upon induction of tax expression, Jurkat T …