Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria
In experimental and human renal diseases, progression is limited by angiotensin-converting
enzyme inhibitors. Whether renoprotection was due to their capacity of reducing
proinflammatory and profibrotic effects of angiotensin II (Ang II) or limiting proteinuria and its
long term toxicity is debated. For dissecting the relative contribution of Ang II and proteinuria
to chronic renal damage, the protein-overload proteinuria model was used in genetically
modified mice lacking the major isoform of murine AT1 receptor (AT 1A). Uninephrectomized …
enzyme inhibitors. Whether renoprotection was due to their capacity of reducing
proinflammatory and profibrotic effects of angiotensin II (Ang II) or limiting proteinuria and its
long term toxicity is debated. For dissecting the relative contribution of Ang II and proteinuria
to chronic renal damage, the protein-overload proteinuria model was used in genetically
modified mice lacking the major isoform of murine AT1 receptor (AT 1A). Uninephrectomized …