Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5: a human chemokine with a regulatory role
V Petkovic, C Moghini, S Paoletti, M Uguccioni… - Journal of Biological …, 2004 - ASBMB
Eotaxin-3 (CCL26), like eotaxin (CCL11) and eotaxin-2 (CCL24), has long been considered
a specific agonist for CC chemokine receptor 3 (CCR3), attracting and activating
eosinophils, basophils, and Th2 type T lymphocytes. Although not characterized extensively
yet, its expression profile coincides with a potential role in allergic inflammation. We recently
reported that eotaxin-3 is an antagonist for CCR2 (Ogilvie, P., Paoletti, S., Clark-Lewis, I.,
and Uguccioni, M.(2003) Blood 102, 789–784). In the present report, we provide evidence …
a specific agonist for CC chemokine receptor 3 (CCR3), attracting and activating
eosinophils, basophils, and Th2 type T lymphocytes. Although not characterized extensively
yet, its expression profile coincides with a potential role in allergic inflammation. We recently
reported that eotaxin-3 is an antagonist for CCR2 (Ogilvie, P., Paoletti, S., Clark-Lewis, I.,
and Uguccioni, M.(2003) Blood 102, 789–784). In the present report, we provide evidence …
