[HTML][HTML] A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without …
S Ogawa, A Oku, A Sawano, S Yamaguchi… - Journal of Biological …, 1998 - ASBMB
Vascular endothelial growth factor (VEGF) mediates endothelial cell proliferation,
angiogenesis, and vascular permeability via the endothelial cell receptors, KDR/Flk-1 and
Flt-1. Recently, a gene encoding a polypeptide with about 25% amino acid identity to
mammalian VEGF was identified in the genome of Orf virus (OV), a parapoxvirus that affects
sheep and goats and occasionally, humans, to generate lesions with angiogenesis. In this
study, we examined the biological activities and receptor of OV-derived NZ-7 VEGF (VEGF …
angiogenesis, and vascular permeability via the endothelial cell receptors, KDR/Flk-1 and
Flt-1. Recently, a gene encoding a polypeptide with about 25% amino acid identity to
mammalian VEGF was identified in the genome of Orf virus (OV), a parapoxvirus that affects
sheep and goats and occasionally, humans, to generate lesions with angiogenesis. In this
study, we examined the biological activities and receptor of OV-derived NZ-7 VEGF (VEGF …