Changes in enteric neurons containing various neurotransmitters in the colon have been
described in diabetic rats; however, how these changes are related to colonic motility
disorders remains unclear. Nitric oxide (NO) is known to be an important inhibitory
neurotransmitter in the enteric nervous system. In the present study, we investigated the
peristaltic reflex using our modified Trendelenburg's method to evaluate the differences in
enteric nitrergic neurons of the distal colon between spontaneously diabetic rats and their …