[HTML][HTML] Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
D Moechars, I Dewachter, K Lorent, D Reversé… - Journal of Biological …, 1999 - ASBMB
Transgenic mice overexpressing different forms of amyloid precursor protein (APP), ie wild
type or clinical mutants, displayed an essentially comparable early phenotype in terms of
behavior, differential glutamatergic responses, deficits in maintenance of long term
potentiation, and premature death. The cognitive impairment, demonstrated in F1 hybrids of
the different APP transgenic lines, was significantly different from nontransgenic littermates
as early as 3 months of age. Biochemical analysis of secreted and membrane-bound APP, C …
type or clinical mutants, displayed an essentially comparable early phenotype in terms of
behavior, differential glutamatergic responses, deficits in maintenance of long term
potentiation, and premature death. The cognitive impairment, demonstrated in F1 hybrids of
the different APP transgenic lines, was significantly different from nontransgenic littermates
as early as 3 months of age. Biochemical analysis of secreted and membrane-bound APP, C …