[HTML][HTML] Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
X Wang, KD McCullough, TF Franke… - Journal of Biological …, 2000 - ASBMB
The serine/threonine kinase Akt (also known as protein kinase B) is activated in response to
various stimuli by a mechanism involving phosphoinositide 3-kinase (PI3-K). Akt provides a
survival signal that protects cells from apoptosis induced by growth factor withdrawal, but its
function in other forms of stress is less clear. Here we investigated the role of PI3-K/Akt
during the cellular response to oxidant injury. H 2 O 2 treatment elevated Akt activity in
multiple cell types in a time-(5–30 min) and dose (400 μM-2 mm)-dependent manner …
various stimuli by a mechanism involving phosphoinositide 3-kinase (PI3-K). Akt provides a
survival signal that protects cells from apoptosis induced by growth factor withdrawal, but its
function in other forms of stress is less clear. Here we investigated the role of PI3-K/Akt
during the cellular response to oxidant injury. H 2 O 2 treatment elevated Akt activity in
multiple cell types in a time-(5–30 min) and dose (400 μM-2 mm)-dependent manner …