A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes
Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in glyceroneogenesis, an
important metabolic pathway that functions to restrain the release of non-esterified fatty acids
(NEFAs) from adipocytes. The antidiabetic drugs known as thiazolidinediones (TZDs) are
thought to achieve some of their benefits by lowering elevated plasma NEFAs. Moreover,
peroxisome proliferator activated receptor γ (PPARγ) mediates the antidiabetic effects of
TZDs, though many TZD responses appear to occur via PPARγ-independent pathways …
important metabolic pathway that functions to restrain the release of non-esterified fatty acids
(NEFAs) from adipocytes. The antidiabetic drugs known as thiazolidinediones (TZDs) are
thought to achieve some of their benefits by lowering elevated plasma NEFAs. Moreover,
peroxisome proliferator activated receptor γ (PPARγ) mediates the antidiabetic effects of
TZDs, though many TZD responses appear to occur via PPARγ-independent pathways …