[HTML][HTML] Peroxisome proliferator-activated receptor α controls cellular cholesterol trafficking in macrophages
G Chinetti-Gbaguidi, E Rigamonti, L Helin… - Journal of lipid …, 2005 - ASBMB
The mobilization of cholesterol from intracellular pools to the plasma membrane is a
determinant that governs its availability for efflux to extracellular acceptors. NPC1 and NPC2
are proteins localized in the late endosome and control cholesterol transport from the
lysosome to the plasma membrane. Here, we report that NPC1 and NPC2 gene expression
is induced by oxidized LDL (OxLDL) in human macrophages. Because OxLDLs contain
natural activators of peroxisome proliferator-activated receptor α (PPARα), a fatty acid …
determinant that governs its availability for efflux to extracellular acceptors. NPC1 and NPC2
are proteins localized in the late endosome and control cholesterol transport from the
lysosome to the plasma membrane. Here, we report that NPC1 and NPC2 gene expression
is induced by oxidized LDL (OxLDL) in human macrophages. Because OxLDLs contain
natural activators of peroxisome proliferator-activated receptor α (PPARα), a fatty acid …