[HTML][HTML] Combinatorial control of gene expression by nuclear receptors and coregulators
NJ McKenna, BW O'Malley - Cell, 2002 - cell.com
Cell, 2002•cell.com
The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in
response to endocrine signaling, and recruitment of coregulators affords these receptors
considerable functional flexibility. We will place historical aspects of NR research in context
with current opinions on their mechanism of signal transduction, and we will speculate upon
future trends in the field.
response to endocrine signaling, and recruitment of coregulators affords these receptors
considerable functional flexibility. We will place historical aspects of NR research in context
with current opinions on their mechanism of signal transduction, and we will speculate upon
future trends in the field.
Abstract
The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in response to endocrine signaling, and recruitment of coregulators affords these receptors considerable functional flexibility. We will place historical aspects of NR research in context with current opinions on their mechanism of signal transduction, and we will speculate upon future trends in the field.
cell.com