Steroid receptor interactions with heat shock protein and immunophilin chaperones

WB Pratt, DO Toft - Endocrine reviews, 1997 - academic.oup.com
WB Pratt, DO Toft
Endocrine reviews, 1997academic.oup.com
I. Introduction II. 9S Receptors A. Estrogen receptors (ERs) B. Progesterone receptors (PRs)
C. Androgen receptors (ARs) D. Glucocorticoid receptors (GRs) E. Mineralocorticoid
receptors (MRs) F. Dioxin receptors (DRs) G. Antheridiol receptors III. Receptor
Transformation A. Transformed receptors bind polyanions B. Artifactual transforming
conditions C. Models of cytosolic receptor transformation D. Physiological relevance of
receptor transformation before the discovery of hsp90 binding IV. Molybdate Stabilization of …
I. Introduction II. 9S Receptors A. Estrogen receptors (ERs) B. Progesterone receptors (PRs) C. Androgen receptors (ARs) D. Glucocorticoid receptors (GRs) E. Mineralocorticoid receptors (MRs) F. Dioxin receptors (DRs) G. Antheridiol receptors III. Receptor Transformation A. Transformed receptors bind polyanions B. Artifactual transforming conditions C. Models of cytosolic receptor transformation D. Physiological relevance of receptor transformation before the discovery of hsp90 binding IV. Molybdate Stabilization of Receptors A. Stabilization of steroid binding activity B. Inhibition of transformation C. Mechanism of molybdate stabilization V. Purification of Untransformed Receptors Leads to hsp90 A. The untransformed receptor is a heterocomplex B. Antibodies against the 90-kDa protein C. The 90-kDa receptor-associated protein is hsp90 VI. Role of hsp90 in Receptor Function A. General properties of hsp90 B. Stoichiometry of receptorhsp90 complex C. hsp90 Binds to the receptor HBD D. Region of hsp90 that binds receptor E. Requirement of hsp90 for steroid binding F. Receptor transformation and hsp90 dissociation G. Receptor inactivation by hsp90 H. Evidence that hsp90 is a physiologically significant regulator of receptor function I. Potential roles of hsp90 in receptor turnover and trafficking
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