Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole
body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux,
and possess both anti-inflammatory and antidiabetic actions. Accordingly, LXR is
considered an appealing drug target for multiple indications. Synthetic LXR agonists
demonstrated inhibition of atherosclerosis progression in murine genetic models; however,
these and other studies indicated that their major undesired side effect is an increase of …