Liver X receptors (LXRs) play key roles in the regulation of cholesterol homeostasis by
limiting cholesterol accumulation in macrophages within arterial wall lesion sites by a
mechanism that includes the upregulation of ATP binding cassette transporters. These
atheroprotective properties distinguish LXRs as potential targets for pharmaceutical
intervention in cardiovascular disease. Their associated activity for promoting lipogenesis
and triglyceride accretion through the activation of sterol-response element binding protein …