[HTML][HTML] The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c
H Jakel, M Nowak, E Moitrot, H Dehondt… - Journal of Biological …, 2004 - ASBMB
Alterations in the expression of the recently discovered apolipoprotein A5 gene strongly
affect plasma triglyceride levels. In this study, we investigated the contribution of APOA5 to
the liver X receptor (LXR) ligand-mediated effect on plasma triglyceride levels. Following
treatment with the LXR ligand T0901317, we found that APOA5 mRNA levels were
decreased in hepatoma cell lines. The observation that no down-regulation of APOA5
promoter activity was obtained by LXR-retinoid X receptor (RXR) co-transfection prompted …
affect plasma triglyceride levels. In this study, we investigated the contribution of APOA5 to
the liver X receptor (LXR) ligand-mediated effect on plasma triglyceride levels. Following
treatment with the LXR ligand T0901317, we found that APOA5 mRNA levels were
decreased in hepatoma cell lines. The observation that no down-regulation of APOA5
promoter activity was obtained by LXR-retinoid X receptor (RXR) co-transfection prompted …