A potential role for sterol 27-hydroxylase in atherogenesis
CM Shanahan, KLH Carpenter, NRB Cary - Atherosclerosis, 2001 - Elsevier
Objective: 27-hydroxycholesterol is the product of the mitochondrial cytochrome P450 sterol
27-hydroxylase, a key enzyme in cholesterol metabolism present in most tissues of the body.
27-hydroxycholesterol increases in abundance with progression of human atherosclerotic
lesions, therefore the aim of this study was to determine the pattern of sterol 27-hydroxylase
gene expression in normal and diseased arteries and to identify the cell types responsible
for its expression. Methods: Reverse transcription-polymerase chain reaction (RT-PCR) …
27-hydroxylase, a key enzyme in cholesterol metabolism present in most tissues of the body.
27-hydroxycholesterol increases in abundance with progression of human atherosclerotic
lesions, therefore the aim of this study was to determine the pattern of sterol 27-hydroxylase
gene expression in normal and diseased arteries and to identify the cell types responsible
for its expression. Methods: Reverse transcription-polymerase chain reaction (RT-PCR) …