[HTML][HTML] Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1α: functional implications in hepatic …
S Bhalla, C Ozalp, S Fang, L Xiang… - Journal of Biological …, 2004 - ASBMB
Previous studies show that feedback inhibition of bile acid production by bile acids is
mediated by multiple mechanisms, including activation of pregnane X receptor (PXR).
Consistent with these studies, the antibiotic rifampicin, a ligand for human PXR, reduces
hepatic bile acid levels in cholestasis patients. To delineate the mechanisms underlying
PXR-mediated suppression of bile acid biosynthesis, we examined the functional cross-talk
between human PXR and HNF-4, a key hepatic activator of genes involved in bile acid …
mediated by multiple mechanisms, including activation of pregnane X receptor (PXR).
Consistent with these studies, the antibiotic rifampicin, a ligand for human PXR, reduces
hepatic bile acid levels in cholestasis patients. To delineate the mechanisms underlying
PXR-mediated suppression of bile acid biosynthesis, we examined the functional cross-talk
between human PXR and HNF-4, a key hepatic activator of genes involved in bile acid …