Crry is a potent complement regulator in rodents that inhibits C3 convertases. In rats,
intrarenal arterial injection of anti-glomerular endothelial cell (GEN) antibodies leads to
complement-dependent microvascular injury and acute renal failure. In this study, a mouse
variant of this model and the effects of complement inhibition were examined. Transgenic
mice that overexpressed soluble Crry systemically and in their kidneys were studied. Anti-
GEN IgG was injected intravenously into eight Crry transgenic mice and seven transgene …