[5] Measurement of thromboxane metabolites by gas chromatography-mass spectrometry
F Catella, GA Fitzgerald - Methods in enzymology, 1990 - Elsevier
Publisher Summary The chapter presents a study on measurement of thromboxane
metabolites by gas chromatography-mass spectrometry (GC-MS). Thromboxane (Tx) A 2 is a
potent vasoconstrictor and proaggregatory substance that, by virtue of these properties, may
play a role in human syndromes of vascular occlusion. Aspirin (acetylsalicylic acid) that
inhibits TxA 2, has proved to be beneficial in syndromes associated with platelet activation,
such as unstable angina. Measurement of 2, 3-dinor-TxBz and 1 l-dehydro-TxB 2 can be …
metabolites by gas chromatography-mass spectrometry (GC-MS). Thromboxane (Tx) A 2 is a
potent vasoconstrictor and proaggregatory substance that, by virtue of these properties, may
play a role in human syndromes of vascular occlusion. Aspirin (acetylsalicylic acid) that
inhibits TxA 2, has proved to be beneficial in syndromes associated with platelet activation,
such as unstable angina. Measurement of 2, 3-dinor-TxBz and 1 l-dehydro-TxB 2 can be …