The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal …
F Squadrito, D Altavilla, N Morabito, A Crisafulli… - Atherosclerosis, 2002 - Elsevier
The phytoestrogen genistein improves endothelial dysfunction in ovariectomized rats
through a nitric oxide-dependent mechanism. We investigated whether genistein alters the
balance between the nitric oxide products and endothelin-1 and influences endothelium-
dependent vasodilation in postmenopausal women. Sixty healthy postmenopausal women
were enrolled in the study. A double-blind, placebo controlled, randomized design was
employed. After a 4-week stabilization on a standard fat-reduced diet, participants to the …
through a nitric oxide-dependent mechanism. We investigated whether genistein alters the
balance between the nitric oxide products and endothelin-1 and influences endothelium-
dependent vasodilation in postmenopausal women. Sixty healthy postmenopausal women
were enrolled in the study. A double-blind, placebo controlled, randomized design was
employed. After a 4-week stabilization on a standard fat-reduced diet, participants to the …