Fatty acid elongases in mammals: their regulation and roles in metabolism
A Jakobsson, R Westerberg, A Jacobsson - Progress in lipid research, 2006 - Elsevier
A significant amount of the fatty acids synthesized by the cytosolic enzyme complex fatty acid
synthase (FAS) or taken up by the diet are further elongated into very long chain fatty acids
(VLCFA) in a four-step reaction cycle by membrane-bound enzymes predominantly located
in the endoplasmic reticulum. Members of the Elovl (elongation-of-very-long-chain-fatty
acids) gene family encode for enzymes (elongases), which are believed to perform the first,
regulatory, step (condensation) in the elongation cycle in mammals. The family of enzymes …
synthase (FAS) or taken up by the diet are further elongated into very long chain fatty acids
(VLCFA) in a four-step reaction cycle by membrane-bound enzymes predominantly located
in the endoplasmic reticulum. Members of the Elovl (elongation-of-very-long-chain-fatty
acids) gene family encode for enzymes (elongases), which are believed to perform the first,
regulatory, step (condensation) in the elongation cycle in mammals. The family of enzymes …