Effects of nutrients and insulin on transcriptional and post-transcriptional regulation of glucose-6-phosphate dehydrogenase synthesis in rat liver
A Katsurada, N Iritani, H Fukuda, Y Matsumura… - … et Biophysica Acta (BBA …, 1989 - Elsevier
The transcriptional and post-transcriptional regulation of glucose-6-phosphate
dehydrogenase induction of rat liver was investigated using a cDNA cloned in our
laboratory. By feeding a carbohydrate/protein diet to fasted rats, the mRNA concentration
and enzyme induction of glucose-6-phosphate dehydrogenase (EC 1.1. 1.49) reached
maximal levels about 10-fold those in the fasted rats at 16 h and 72 h, respectively, whereas
the transcriptional rate was increased about 3-fold in 6 h. In the protein fed (without …
dehydrogenase induction of rat liver was investigated using a cDNA cloned in our
laboratory. By feeding a carbohydrate/protein diet to fasted rats, the mRNA concentration
and enzyme induction of glucose-6-phosphate dehydrogenase (EC 1.1. 1.49) reached
maximal levels about 10-fold those in the fasted rats at 16 h and 72 h, respectively, whereas
the transcriptional rate was increased about 3-fold in 6 h. In the protein fed (without …