[HTML][HTML] Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone …
K Balasubramanyam, RA Varier, M Altaf… - Journal of Biological …, 2004 - ASBMB
Acetylation of histones and non-histone proteins is an important post-translational
modification involved in the regulation of gene expression in eukaryotes and all viral DNA
that integrates into the human genome (eg the human immunodeficiency virus). Dysfunction
of histone acetyltransferases (HATs) is often associated with the manifestation of several
diseases. In this respect, HATs are the new potential targets for the design of therapeutics. In
this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice …
modification involved in the regulation of gene expression in eukaryotes and all viral DNA
that integrates into the human genome (eg the human immunodeficiency virus). Dysfunction
of histone acetyltransferases (HATs) is often associated with the manifestation of several
diseases. In this respect, HATs are the new potential targets for the design of therapeutics. In
this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice …