The influence of glutathione and other thiols on human platelet aggregation
G Thomas, VA Skrinska, FV Lucas - Thrombosis research, 1986 - Elsevier
The platelet membrane contains sulfhydryl groups which are essential for normal platelet
function. Reduced glutathione (GSH) and other thiols such as cysteine and 6-
mercaptopurine were found to inhibit human platelet aggregation induced by adenosine
diphosphate (ADP), collagen and arachidonic acid. The inhibition of ADP-induced
aggregation by GSH (IC 50= 0.61±0.05 mM) was greater than that by cysteine (IC 50= 13±1
mM) or 6-mercaptopurine (IC 50= 5.4±0.2 mM). Two other thiols, dithiothreitol and beta …
function. Reduced glutathione (GSH) and other thiols such as cysteine and 6-
mercaptopurine were found to inhibit human platelet aggregation induced by adenosine
diphosphate (ADP), collagen and arachidonic acid. The inhibition of ADP-induced
aggregation by GSH (IC 50= 0.61±0.05 mM) was greater than that by cysteine (IC 50= 13±1
mM) or 6-mercaptopurine (IC 50= 5.4±0.2 mM). Two other thiols, dithiothreitol and beta …