Glycogen synthase kinase-3 inactivation and stabilization of β-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes

S Kuure, A Popsueva, M Jakobson… - Journal of the …, 2007 - journals.lww.com
Wnt proteins are required for induction of nephrons in mouse metanephric kidneys, but the
downstream pathways that mediate tubule induction and epithelial differentiation have
remained obscure. The intracellular mechanisms by which Wnt signaling mediates nephron
induction in embryonic kidney mesenchymes were studied. First is shown that transient
exposure of isolated kidney mesenchymes to structurally different glycogen synthase kinase-
3 (GSK3) inhibitors lithium or 6-bromoindirubin-3′-oxime results in abundant epithelial …