5-Aryl-pyrazolo [3, 4-b] pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
J Witherington, V Bordas, D Haigh, DMB Hickey… - Bioorganic & medicinal …, 2003 - Elsevier
J Witherington, V Bordas, D Haigh, DMB Hickey, RJ Ife, AD Rawlings, BP Slingsby…
Bioorganic & medicinal chemistry letters, 2003•ElsevierIntroduction of a nitrogen atom into the 6-position of a series of pyrazolo [3, 4-b] pyridines led
to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding
mode suggested participation of a putative structural water molecule, which was
subsequently confirmed by X-ray crystallography.
to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding
mode suggested participation of a putative structural water molecule, which was
subsequently confirmed by X-ray crystallography.
Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.
Elsevier