[HTML][HTML] Proteins homologous to p47phox and p67phox support superoxide production by NAD (P) H oxidase 1 in colon epithelial cells
M Geiszt, K Lekstrom, J Witta, TL Leto - Journal of Biological Chemistry, 2003 - ASBMB
Superoxide production by phagocytes involves activation of a multi-component NADPH
oxidase. Recently, several homologues of the catalytic component of the phagocyte oxidase,
gp91 phox, were identified in various tissues. Here we describe two proteins, p41 and p51,
with significant homology to two cytosolic components of the phagocytic oxidase, p47 phox
and p67 phox. Like p47 phox, p41 contains an amino-terminal Phox homology domain, two
SH3 domains, and a conserved carboxyl-terminal, proline-rich motif. Similarly, p51 is …
oxidase. Recently, several homologues of the catalytic component of the phagocyte oxidase,
gp91 phox, were identified in various tissues. Here we describe two proteins, p41 and p51,
with significant homology to two cytosolic components of the phagocytic oxidase, p47 phox
and p67 phox. Like p47 phox, p41 contains an amino-terminal Phox homology domain, two
SH3 domains, and a conserved carboxyl-terminal, proline-rich motif. Similarly, p51 is …