[HTML][HTML] Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases
R Takeya, N Ueno, K Kami, M Taura, M Kohjima… - Journal of Biological …, 2003 - ASBMB
The catalytic core of a superoxide-producing NADPH oxidase (Nox) in phagocytes is gp91
phox/Nox2, a membrane-integrated protein that forms a heterodimer with p22 phox to
constitute flavocytochrome b 558. The cytochrome becomes activated by interacting with the
adaptor proteins p47 phox and p67 phox as well as the small GTPase Rac. Here we
describe the cloning of human cDNAs for novel proteins homologous to p47 phox and p67
phox, designated p41 nox and p51 nox, respectively; the former is encoded by NOXO1 (Nox …
phox/Nox2, a membrane-integrated protein that forms a heterodimer with p22 phox to
constitute flavocytochrome b 558. The cytochrome becomes activated by interacting with the
adaptor proteins p47 phox and p67 phox as well as the small GTPase Rac. Here we
describe the cloning of human cDNAs for novel proteins homologous to p47 phox and p67
phox, designated p41 nox and p51 nox, respectively; the former is encoded by NOXO1 (Nox …