[HTML][HTML] The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1
C Zhu, G Saberwal, YF Lu, LC Platanias… - Journal of Biological …, 2004 - ASBMB
Deficiency of the interferon consensus sequence-binding protein (ICSBP) is associated with
increased myeloid cell proliferation in response to hematopoietic cytokines. However,
previously identified ICSBP target genes do not indicate a mechanism for this" cytokine
hypersen-sitivity." In these studies, we identify the gene encoding neurofibromin 1 (Nf1) as
an ICSBP target gene, by chromatin immunoprecipitation. Additionally, we find decreased
Nf1 expression in bone marrow-derived myeloid cells from ICSBP–/–mice. Since Nf1 …
increased myeloid cell proliferation in response to hematopoietic cytokines. However,
previously identified ICSBP target genes do not indicate a mechanism for this" cytokine
hypersen-sitivity." In these studies, we identify the gene encoding neurofibromin 1 (Nf1) as
an ICSBP target gene, by chromatin immunoprecipitation. Additionally, we find decreased
Nf1 expression in bone marrow-derived myeloid cells from ICSBP–/–mice. Since Nf1 …