Decorin is not only a regulator of matrix assembly but also a key signaling molecule that
modulates the activity of tyrosine kinase receptors such as the epidermal growth factor
receptor (EGFR). Decorin evokes protracted internalization of the EGFR via a caveolar-
mediated endocytosis, which leads to EGFR degradation and attenuation of its signaling
pathway. In this study, we tested if systemic delivery of decorin protein core would affect the
biology of an orthotopic squamous carcinoma xenograft. After tumor engraftment, the …