[HTML][HTML] Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages
J Wang, E Guan, G Roderiquez, V Calvert… - Journal of Biological …, 2001 - ASBMB
The chemokine stromal cell-derived factor (SDF)-1 and its receptor, CXCR4, play important
roles in human immunodeficiency virus type 1 (HIV-1) pathophysiology, leukocyte trafficking,
inflammation, hematopoiesis, embryogenesis, angiogenesis, and cancer metastasis. The
effects of cytokines on the regulation of CXCR4 function were investigated in human primary
monocytes-macrophages. The expression of functional CXCR4 on the cell surface was
demonstrated by the detection of ligand-induced Ca 2+ mobilization, chemotaxis, and ligand …
roles in human immunodeficiency virus type 1 (HIV-1) pathophysiology, leukocyte trafficking,
inflammation, hematopoiesis, embryogenesis, angiogenesis, and cancer metastasis. The
effects of cytokines on the regulation of CXCR4 function were investigated in human primary
monocytes-macrophages. The expression of functional CXCR4 on the cell surface was
demonstrated by the detection of ligand-induced Ca 2+ mobilization, chemotaxis, and ligand …