[HTML][HTML] Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
J Huber, A Fuärnkranz, VN Bochkov, MK Patricia… - Journal of lipid …, 2006 - ASBMB
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils,
an initiating event in atherogenesis. Here, we investigate intracellular signaling events
induced by oxidized phospholipids in human umbilical vein endothelial cells (HUVECs) that
lead to specific monocyte adhesion. In a static adhesion assay, oxidized 1-palmitoyl-2-
arachidonoyl-sn-glycero-3-phosphorylcholine and one of its components, 1-palmitoyl-2-
oxovaleroyl-sn-glycero-3-phosphorylcholine, stimulated HUVECs to bind U937 cells and …
an initiating event in atherogenesis. Here, we investigate intracellular signaling events
induced by oxidized phospholipids in human umbilical vein endothelial cells (HUVECs) that
lead to specific monocyte adhesion. In a static adhesion assay, oxidized 1-palmitoyl-2-
arachidonoyl-sn-glycero-3-phosphorylcholine and one of its components, 1-palmitoyl-2-
oxovaleroyl-sn-glycero-3-phosphorylcholine, stimulated HUVECs to bind U937 cells and …