Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species
DE Doran, D Weiss, Y Zhang, KK Griendling… - Atherosclerosis, 2007 - Elsevier
Angiotensin II receptor blockade has been shown to inhibit atherosclerosis in several
different animal models. We sought to determine if this effect was the result of blood
pressure reduction per se or a result of the anti-inflammatory effects of receptor blockade.
ApoE-deficient mice were fed a high fat diet and treated with either an angiotensin II receptor
antagonist, candesartan (0.5 mg/kg/day, SC) or a calcium channel blocker, amlodipine (7.5
mg/kg/day, mixed with food). Atherosclerotic lesion area, aortic inflammatory gene …
different animal models. We sought to determine if this effect was the result of blood
pressure reduction per se or a result of the anti-inflammatory effects of receptor blockade.
ApoE-deficient mice were fed a high fat diet and treated with either an angiotensin II receptor
antagonist, candesartan (0.5 mg/kg/day, SC) or a calcium channel blocker, amlodipine (7.5
mg/kg/day, mixed with food). Atherosclerotic lesion area, aortic inflammatory gene …