Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation
V da Cunha, DM Tham, B Martin-McNulty, G Deng… - Atherosclerosis, 2005 - Elsevier
Angiotensin converting enzyme (ACE) inhibitors prevent a wide variety of key events
underlying atherogenesis. Whether these actions depend solely on reduction of angiotensin
II (Ang II) generation is still to be determined. This study was undertaken to determine
whether enalapril, an ACE inhibitor, prevents atherosclerosis and vascular inflammation
induced by Ang II in apolipoprotein E-deficient (apoE-KO) mice. Subcutaneous infusion of
Ang II (1.44 mg/(kgday)) for 4 weeks increased blood pressure and accelerated …
underlying atherogenesis. Whether these actions depend solely on reduction of angiotensin
II (Ang II) generation is still to be determined. This study was undertaken to determine
whether enalapril, an ACE inhibitor, prevents atherosclerosis and vascular inflammation
induced by Ang II in apolipoprotein E-deficient (apoE-KO) mice. Subcutaneous infusion of
Ang II (1.44 mg/(kgday)) for 4 weeks increased blood pressure and accelerated …