[HTML][HTML] Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes
M Baqui, D Botero, B Gereben, C Curcio… - Journal of Biological …, 2003 - ASBMB
The type 3 iodothyronine selenodeiodinase (D3) is an integral membrane protein that
inactivates thyroid hormones. By using immunofluorescence cytochemistry confocal
microscopy of live or fixed cells transiently expressing FLAG-tagged human D3 or monkey
hepatocarcinoma cells expressing endogenous D3, we identified D3 in the plasma
membrane. It co-localizes with Na, K-ATPase α, with the early endosomal marker EEA-1 and
clathrin, but not with two endoplasmic reticulum resident proteins. Most of the D3 molecule is …
inactivates thyroid hormones. By using immunofluorescence cytochemistry confocal
microscopy of live or fixed cells transiently expressing FLAG-tagged human D3 or monkey
hepatocarcinoma cells expressing endogenous D3, we identified D3 in the plasma
membrane. It co-localizes with Na, K-ATPase α, with the early endosomal marker EEA-1 and
clathrin, but not with two endoplasmic reticulum resident proteins. Most of the D3 molecule is …