[HTML][HTML] BCL-3 and NF-κB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages
J Wessells, M Baer, HA Young, E Claudio… - Journal of Biological …, 2004 - ASBMB
Lipopolysaccharide (LPS) induces expression of tumor necrosis factor α (TNFα) and other
pro-inflammatory cytokines in macrophages. Following its induction, TNFα gene
transcription is rapidly attenuated, in part due to the accumulation of NF-κB p50 homodimers
that bind to three κB sites in the TNFα promoter. Here we have investigated the inhibitory
role of BCL-3, an IκB-like protein that interacts exclusively with p50 and p52 homodimers.
BCL-3 was induced by LPS with delayed kinetics and was associated with p50 in the …
pro-inflammatory cytokines in macrophages. Following its induction, TNFα gene
transcription is rapidly attenuated, in part due to the accumulation of NF-κB p50 homodimers
that bind to three κB sites in the TNFα promoter. Here we have investigated the inhibitory
role of BCL-3, an IκB-like protein that interacts exclusively with p50 and p52 homodimers.
BCL-3 was induced by LPS with delayed kinetics and was associated with p50 in the …