[HTML][HTML] Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
JL Eyles, D Metcalf, MJ Grusby, DJ Hilton… - Journal of Biological …, 2002 - ASBMB
Suppressor of cytokine signaling-1 (SOCS-1) is an inhibitory protein that regulates
responses to cytokines. Previously, we have shown SOCS-1 to be a key inhibitor of
interferon γ (IFNγ). Recent data suggest that SOCS-1 may regulate other cytokines in vivo, in
addition to IFNγ. Uncontrolled responses to interleukin-12 (IL-12), an inflammatory cytokine,
could contribute to increased IFNγ production and the development of inflammatory disease
in SOCS-1−/− mice. Here, we assess responses of SOCS-1-deficient cells to IL-12. Both IL …
responses to cytokines. Previously, we have shown SOCS-1 to be a key inhibitor of
interferon γ (IFNγ). Recent data suggest that SOCS-1 may regulate other cytokines in vivo, in
addition to IFNγ. Uncontrolled responses to interleukin-12 (IL-12), an inflammatory cytokine,
could contribute to increased IFNγ production and the development of inflammatory disease
in SOCS-1−/− mice. Here, we assess responses of SOCS-1-deficient cells to IL-12. Both IL …