Repair of DNA double strand breaks by non-homologous end joining
SP Lees-Miller, K Meek - Biochimie, 2003 - Elsevier
DNA double strand breaks (DSB) are the most serious form of DNA damage. If not repaired
they can lead to cell death. If misrepaired DSBs contribute to chromosomal aberrations and
genomic instability. Non-homologous end joining (NHEJ) is one of two major pathways for
the repair of DSBs in human cells. Proteins known to be required for NHEJ include the DNA-
dependent protein kinase (DNA-PK), XRCC4, DNA ligase IV, and Artemis. This review
discusses how these and other accessory proteins may function in the repair of DSBs …
they can lead to cell death. If misrepaired DSBs contribute to chromosomal aberrations and
genomic instability. Non-homologous end joining (NHEJ) is one of two major pathways for
the repair of DSBs in human cells. Proteins known to be required for NHEJ include the DNA-
dependent protein kinase (DNA-PK), XRCC4, DNA ligase IV, and Artemis. This review
discusses how these and other accessory proteins may function in the repair of DSBs …