[HTML][HTML] CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells
N Petrovic, SV Bhagwat, WJ Ratzan… - Journal of Biological …, 2003 - ASBMB
CD13/aminopeptidase N (CD13/APN) is a potent regulator of angiogenesis both in vitro and
in vivo and transcription of CD13/APN in endothelial cells is induced by angiogenic growth
factors via the RAS/MAPK pathway. We have explored the nuclear effectors downstream of
this pathway that are responsible for CD13/APN induction. The response to
serum/angiogenic growth factors mapped to a 38-bp region of the CD13/APN promoter
containing an Ets-core motif that specifically binds a protein complex from nuclear lysates …
in vivo and transcription of CD13/APN in endothelial cells is induced by angiogenic growth
factors via the RAS/MAPK pathway. We have explored the nuclear effectors downstream of
this pathway that are responsible for CD13/APN induction. The response to
serum/angiogenic growth factors mapped to a 38-bp region of the CD13/APN promoter
containing an Ets-core motif that specifically binds a protein complex from nuclear lysates …