Abstract β-Catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are
involved in tumorigenesis. Dysregulation of these pathways allow β-catenin to accumulate
and translocate to the nucleus, where it may activate oncogenes. Such nuclear
accumulation can be detected by immunohistochemistry, which may be useful in diagnosis.
Although the role of β-catenin has been established in various types of carcinomas,
relatively little is known about its status in mesenchymal tumors. A number of studies …