[HTML][HTML] Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1β/erbB4 signaling
Y Kuramochi, GM Cote, X Guo, NK Lebrasseur… - Journal of Biological …, 2004 - ASBMB
Neuregulin (NRG)-1β has a prosurvival effect on cardiac myocytes via the
phosphatidylinositol-3-kinase/Akt pathway, but the physiological regulators of this system in
the intact heart are unknown. In this study, we tested the hypothesis that reactive oxygen
species regulate NRG/erbB signaling. We used isolated adult rat ventricular myocytes
(ARVMs) or cardiac microvascular endothelial cells (CMECs) in monoculture, or together in
coculture. H 2 O 2 induced NRG-1β release from CMECs in a concentration-dependent …
phosphatidylinositol-3-kinase/Akt pathway, but the physiological regulators of this system in
the intact heart are unknown. In this study, we tested the hypothesis that reactive oxygen
species regulate NRG/erbB signaling. We used isolated adult rat ventricular myocytes
(ARVMs) or cardiac microvascular endothelial cells (CMECs) in monoculture, or together in
coculture. H 2 O 2 induced NRG-1β release from CMECs in a concentration-dependent …