Leukemia in infants

CA Felix, BJ Lange - The Oncologist, 1999 - academic.oup.com
CA Felix, BJ Lange
The Oncologist, 1999academic.oup.com
Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in
common a high incidence of translocations of the MLL gene at chromosome band 11q23.
Similar translocations occur in leukemias associated with chemotherapies that target DNA
topoisomerase II. MLL has numerous different partner genes. The role of the many MLL
fusion proteins in leukemogenesis is not yet understood. The t (4; 11) translocation, the most
common translocation in infant ALL, adversely affects the outcome. Additional genetic …
Abstract
Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in common a high incidence of translocations of the MLL gene at chromosome band 11q23. Similar translocations occur in leukemias associated with chemotherapies that target DNA topoisomerase II. MLL has numerous different partner genes. The role of the many MLL fusion proteins in leukemogenesis is not yet understood. The t(4;11) translocation, the most common translocation in infant ALL, adversely affects the outcome. Additional genetic changes, especially Ikaros alterations, are found in infant ALL. Other forms of myeloid leukemia in infants present as myelodysplastic and myeloproliferative syndromes, which may be associated with constitutional disorders. This review will consider all leukemia in infants, but will focus on leukemias with MLL gene translocations.
Oxford University Press