BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure
MR Davies, RJ Lund, KA Hruska - Journal of the American Society …, 2003 - journals.lww.com
Chronic renal failure is complicated by high cardiovascular mortality. One key contributor to
this mortality is vascular calcification, for which no therapy currently exists. Bone
morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular
differentiation in the adult and is downregulated in renal failure. Several studies have
demonstrated its efficacy in treating various renal diseases in rodents, and it was
hypothesized that it would also be an effective treatment of vascular calcification in this …
this mortality is vascular calcification, for which no therapy currently exists. Bone
morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular
differentiation in the adult and is downregulated in renal failure. Several studies have
demonstrated its efficacy in treating various renal diseases in rodents, and it was
hypothesized that it would also be an effective treatment of vascular calcification in this …