Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
E Masliah, L Hansen, A Adame, L Crews, F Bard… - Neurology, 2005 - AAN Enterprises
E Masliah, L Hansen, A Adame, L Crews, F Bard, C Lee, P Seubert, D Games, L Kirby…
Neurology, 2005•AAN EnterprisesThe authors report a patient with Alzheimer disease (AD) without encephalitis who was
immunized with AN-1792 (an adjuvanted formulation of Aβ-42). There were no amyloid
plaques in the frontal cortex and abundant Aβ-immunoreactive macrophages, but tangles
and amyloid angiopathy were present. The white matter appeared normal and minimal
lymphocytic infiltration in the leptomeninges was observed. This case illustrates the effects of
an Aβ-based immunization on AD pathogenesis in the absence of overt …
immunized with AN-1792 (an adjuvanted formulation of Aβ-42). There were no amyloid
plaques in the frontal cortex and abundant Aβ-immunoreactive macrophages, but tangles
and amyloid angiopathy were present. The white matter appeared normal and minimal
lymphocytic infiltration in the leptomeninges was observed. This case illustrates the effects of
an Aβ-based immunization on AD pathogenesis in the absence of overt …
The authors report a patient with Alzheimer disease (AD) without encephalitis who was immunized with AN-1792 (an adjuvanted formulation of Aβ-42). There were no amyloid plaques in the frontal cortex and abundant Aβ-immunoreactive macrophages, but tangles and amyloid angiopathy were present. The white matter appeared normal and minimal lymphocytic infiltration in the leptomeninges was observed. This case illustrates the effects of an Aβ-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy.
American Academy of Neurology