[HTML][HTML] Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice
L Ragolia, T Palaia, CE Hall, JK Maesaka… - Journal of Biological …, 2005 - ASBMB
Type 2 diabetics have an increased risk of developing atherosclerosis, suggesting the
mechanisms that cause this disease are enhanced by insulin resistance. In this study we
examined the effects of gene knock-out (KO) of lipocalin-type prostaglandin D 2 synthase (L-
PGDS), a protein found at elevated levels in type 2 diabetics, on diet-induced glucose
tolerance and atherosclerosis. Our results show that L-PGDS KO mice become glucose-in-
tolerant and insulin-resistant at an accelerated rate when compared with the C57BL/6 …
mechanisms that cause this disease are enhanced by insulin resistance. In this study we
examined the effects of gene knock-out (KO) of lipocalin-type prostaglandin D 2 synthase (L-
PGDS), a protein found at elevated levels in type 2 diabetics, on diet-induced glucose
tolerance and atherosclerosis. Our results show that L-PGDS KO mice become glucose-in-
tolerant and insulin-resistant at an accelerated rate when compared with the C57BL/6 …
