Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform

AR Sousa, SJ Lane, JA Cidlowski, DZ Staynov… - Journal of Allergy and …, 2000 - Elsevier
Background: Glucocorticoid-resistant bronchial asthma is characterized by failure of
corticosteroids to suppress key asthma-relevant, cell–mediated inflammatory responses in
the airways. Objective: The mechanism of this phenomenon is not clear but may involve
aberrant expression of the β-isoform of the glucocorticoid receptor. Methods: We have
measured expression of the α-and β-glucocorticoid receptor isoforms in tuberculin-driven
cutaneous cell–mediated inflammatory lesions in people with asthma who are glucocorticoid …