Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma

SP Umland, RP Schleimer, SL Johnston - Pulmonary pharmacology & …, 2002 - Elsevier
Asthma is characterized by inflammation in the lung and glucocorticoids (GCs) are the most
clinically effective treatment available. The success of chronic GC therapy for asthma stems
largely from the ability of the GC–GC receptor (GR) complex to alter transcription of a wide
array of molecules involved in the inflammatory process. Many of the adverse effects of
elevated systemic GC levels have been reduced through the use of inhalation as a method
of administration, as opposed to oral GC. GCs exert their effects by binding to the wild-type …