A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients
C Hawrylowicz, D Richards, TK Loke… - Journal of Allergy and …, 2002 - jacionline.org
Corticosteroid-resistant (CR) asthmatic patients who fail to demonstrate improved lung
function after treatment with systemic corticosteroids pose a serious clinical problem. In
corticosteroidsensitive (CS) asthmatic individuals, CD4+ TH2 lymphocytes, which secrete
asthma-promoting cytokines such as IL-4 and IL-5, are an important target of corticosteroid
action. The well-documented effects of corticosteroids in CS asthma appear to be largely
attenuated in CR patients, at least in terms of changes in the numbers of bronchial luminal T …
function after treatment with systemic corticosteroids pose a serious clinical problem. In
corticosteroidsensitive (CS) asthmatic individuals, CD4+ TH2 lymphocytes, which secrete
asthma-promoting cytokines such as IL-4 and IL-5, are an important target of corticosteroid
action. The well-documented effects of corticosteroids in CS asthma appear to be largely
attenuated in CR patients, at least in terms of changes in the numbers of bronchial luminal T …