Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach
M Kojima, H Hosoda, K Kangawa - Best Practice & Research Clinical …, 2004 - Elsevier
Recent identification of novel appetite-regulating hormones has revealed the complex
interactions of these humoral factors in the regulation of feeding behavior in mammals. One
of these hormones, ghrelin, a natural ligand of the orphan receptor GHS-R, purified from
stomach, is able to stimulate growth hormone release from pituitary cells. Ghrelin is a 28
amino acid peptide containing an n-octanoylated serine 3 residue that is essential for its
activity. Ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, the …
interactions of these humoral factors in the regulation of feeding behavior in mammals. One
of these hormones, ghrelin, a natural ligand of the orphan receptor GHS-R, purified from
stomach, is able to stimulate growth hormone release from pituitary cells. Ghrelin is a 28
amino acid peptide containing an n-octanoylated serine 3 residue that is essential for its
activity. Ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, the …