[HTML][HTML] An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2

NP Gerard, B Lu, P Liu, S Craig, Y Fujiwara… - Journal of Biological …, 2005 - ASBMB
C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on
many cells including polymorphonuclear neutrophils. The apparent absence of coupling of
C5L2 with G proteins suggests that this receptor may modulate the biological activity of C5a,
perhaps by acting as a decoy receptor. Alternatively, C5L2 may affect C5a function through
formation of a heteromeric complex with the C5aR, or it may utilize a G protein-independent
signaling pathway. Here we show that in mice bearing a targeted deletion of C5L2, the …